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Emotions aside for players and coaches with both the San Francisco 49ers and Indianapolis Colts, here are five things to watch for Sunday when the two teams face off for the first time since 2010 on Sunday at Candlestick Park at 1:15 p.m. on KPIX 5.
Jim Harbaugh spent the better part of two seasons building gameplans tailored to the strengths of Andrew Luck, who more often than not executed his coach's schemes.
The San Francisco 49ers play the Indianapolis Colts at Candlestick Sunday in a game featuring a former Stanford coach, Jim Harbaugh, and his star college quarterback, Andrew Luck. "Andrew Luck and that Colt offense, they can play," John Madden told the KCBS Radio morning crew.
They will be reunited as opponents Sunday, finding themselves in the strange position of game-planning against each other in Week 3 while trying to bounce back from tough losses.
When Vernon Davis and Jim Harbaugh eye the Colts sideline this Sunday, they will each look a little differently at a player looking back at them. There are two members of the opposition that have close ties to the two, and should make for some interesting football come Sunday.
The San Francisco 49ers have committed 23 penalties in their first two games for 206 yards, 12 of those for 121 yards against the Seattle Seahawks this past Sunday. They were flagged for two personal fouls and an unsportsmanlike conduct penalty in the fourth quarter.
Reporters pressed him with questions anyway related to San Francisco and the late hit on Colin Kaepernick. Asked if he had received word from the NFL on a potential fine, Clay Matthews said he wasn't going to discuss the topic.
Jim Harbaugh offered a parting shot at Packers linebacker Clay Matthews: Slapping is not the tough-guy way.
Colt McCoy said Sunday night that he restructured his contract for the season, and coach Jim Harbaugh named the quarterback San Francisco's backup behind Colin Kaepernick despite an inconsistent preseason.
Colin Kaepernick looked strong in the 49ers' 34-14 exhibition victory over the Vikings on Sunday night
A.J. Jenkins no longer is in a San Francisco 49ers uniform after being dealt to Kansas City. But coach Jim Harbaugh is still coming to the defense of his former receiver.
Jim Harbaugh still believes in Eric Wright. And Wright has joined the San Francisco 49ers after all.
The San Francisco 49ers are No. 1 in the Associated Press NFL power rankings heading into the preseason, with the Denver Broncos second and the Jacksonville Jaguars at the bottom of the list.
Free agent cornerback Eric Wright might end up in a San Francisco 49ers uniform after all. Head coach Jim Harbaugh indicated that the team has had contact with Wright since losing nickel back Chris Culliver to a season-ending knee injury.
It was only a few years ago that the NFC West was the laughingstock of the league, with Seattle snatching a division title in 2010 despite a 7-9 record. The situation was so unsightly that suggestions of altering the playoff seeding system became an off-season talking point.
San Francisco 49ers head coach Harbaugh said he sympathized with Tarell Brown after learning the cornerback lost out on $2 million, and that he believes "there's a solution there."
San Francisco 49ers head coach Jim Harbaugh avoided questions about linebacker Ahmad Brooks' legal issues on Monday.
49ers coach Jim Harbaugh and Seahawks coach Pete Carroll had faced off against each other in Pac-12 play when Stanford played USC.
Jim Harbaugh has used the recent run of suspensions on the division rival Seattle Seahawks for performance-enhancing drug infractions as a reminder to his own San Francisco team: Cheating won't be tolerated.
San Francisco 49ers coach Jim Harbaugh, a huge fan of TV's Judge Judy, describes meeting the no-nonsense judge in her courtroom.
Months after San Francisco 49ers head coach Jim Harbaugh cited television's Judge Judy as his role model for truth-telling, he finally got the opportunity to meet her in person. Harbaugh, accompanied by his father, recently attended a taping of the Judge Judy show at Judy's invitation. The episode airs Monday evening at 7:30 on KPIX 5.
The 49ers lost their top receiver when Michael Crabtree tore his Achilles tendon in practice Tuesday. Coach Jim Harbaugh said Crabtree could return in mid-November. But John Madden told the KCBS Radio morning crew the 49ers should prepare for a full season without him.
San Francisco 49ers coach Jim Harbaugh will return to Indianapolis on Sunday to drive the Indianapolis 500 pace car.
Free agent Charles Woodson signed a one year contract with the Oakland Raiders that could pay the 36-year-old defensive back as much as $4.3 million, including incentives.
The San Francisco 49ers and KPIX 5 announced a new television broadcast agreement on Thursday which includes a 10-year extension of preseason game broadcast rights through the 2023 season.
The Miami Dolphins kept their playoff chances alive by beating the San Francisco 49ers 29-17 on Sunday.
Bay Area airports are expecting a busy holiday traveling period, with the busiest days likely to be the days after Christmas.
The defending NFC champion San Francisco 49ers were eliminated from the playoffs before their game at Miami began on Sunday because of victories by Washington and the Los Angeles Rams.
Suchir Balaji, a former researcher at OpenAI who openly questioned the legality of its data-gathering practices, died by suicide, authorities said.
San Jose police said three people were arrested in connection to organized retail theft on Saturday.
The Miami Dolphins kept their playoff chances alive by beating the San Francisco 49ers 29-17 on Sunday.
Bay Area airports are expecting a busy holiday traveling period, with the busiest days likely to be the days after Christmas.
The defending NFC champion San Francisco 49ers were eliminated from the playoffs before their game at Miami began on Sunday because of victories by Washington and the Los Angeles Rams.
Suchir Balaji, a former researcher at OpenAI who openly questioned the legality of its data-gathering practices, died by suicide, authorities said.
San Jose police said three people were arrested in connection to organized retail theft on Saturday.
At Bay Area food banks, there is a lot riding on the holiday season.
State officials on Friday announced the commercial Dungeness crab fishery for most of the California coast will finally open south of the Sonoma/Mendocino county line beginning Jan. 5.
Police in San Francisco shot and killed a man early Friday morning near Union Square who was wanted for hitting two pedestrians and a man on an electric scooter with a vehicle hours earlier.
A coffee shop in San Francisco's Mission Bay hasn't even opened yet, but has dealt with at least two break-ins over a 24-hour span.
San Mateo County emergency officials are developing a new method of communication to reduce misinformation and confusion during earthquake and tsunami threats, following a massive earthquake that struck near Humboldt County in early December.
Bay Area airports are expecting a busy holiday traveling period, with the busiest days likely to be the days after Christmas.
In the Bay Area, the light rain might have kept some shoppers home, but some were out finishing up their holiday shopping.
Oakland police said two people were killed Friday night after an altercation involving multiple people.
Fremont's recently elected Mayor Raj Salwan is blazing a new trail as the first Indian-American to lead the East Bay city.
An East Bay CHP officer recently had to play Grinch after spotting a car decorated with exterior Christmas lights traveling on Interstate Highway 880, authorities said.
San Jose police said three people were arrested in connection to organized retail theft on Saturday.
A suspect is in custody after an Amber Alert was issued for two children authorities say were abducted in King City.
A convicted sex offender already serving time at prison may never see life outside bars again after he was found guilty of committing a violent mall robbery more than three decades ago in San Jose.
Police in Milpitas provided an update into the deaths of a family found inside their apartment Tuesday, saying the incident is being investigated as a murder-suicide.
Four family members, two adults and two children, were found dead inside an apartment in Milpitas Tuesday in an incident that police said was "isolated."
The Napa Salvation Army struck gold on Saturday, discovering a rare gold coin worth thousands of dollars in one of its red kettles.
Police in Novato have completed their search of a high school and have secured the campus following a report of a nearby robbery Thursday, but the investigation remains ongoing, the department said.
Service on Sonoma-Marin Area Rail Transit was unavailable Monday because of storm damage and for extended systems testing, the agency said.
Zakir Hussain, one of India's most accomplished classical musicians who defied genres and introduced tabla to a global audience, has died.
A North Bay city experienced a city-wide power outage on Saturday after high winds downed power lines and trees.
The Miami Dolphins kept their playoff chances alive by beating the San Francisco 49ers 29-17 on Sunday.
The defending NFC champion San Francisco 49ers were eliminated from the playoffs before their game at Miami began on Sunday because of victories by Washington and the Los Angeles Rams.
Steph Curry scored 11 straight points in the fourth quarter and 31 for the night as the Golden State Warriors beat the Minnesota Timberwolves 113-103.
Rickey Henderson is widely considered to be one of the best leadoff hitters and base stealers in baseball.
Third baseman Gio Urshela and the Athletics finalized a $2.15 million, one-year contract on Sunday.
San Jose police said three people were arrested in connection to organized retail theft on Saturday.
A person of interest was taken into custody after a woman died after being lit on fire while she was asleep on an F train in Brooklyn, police say.
The suspect drove through the doors of a JCPenny in Killeen, Texas, and continued inside for "several hundred yards," an official said.
Oakland police said two people were killed Friday night after an altercation involving multiple people.
A road rage incident on Interstate Highway 80 in Pinole earlier this month culminated in a shooting on an offramp that severely injured one person, police said Friday.
In the face of wide speculation about how artificial intelligence will impact workers in the Bay Area and beyond, a series of billboards plays on those concerns, advertising what appears to be a nightmare scenario where people are entirely replaced by computers.
Elliston Berry's life was turned upside down after a photo she posted on Instagram was digitally altered online to be pornographic.
FAA data shows that lithium battery fires on U.S. flights have risen 388% since 2015, now occurring nearly twice a week.
Members of Cash App founder Bob Lee's family had sharp criticism Tuesday for those close to Nima Momeni, who was convicted of second-degree murder in Lee's 2023 stabbing death in San Francisco.
Nima Momeni has been found guilty of second-degree murder in the fatal stabbing of Cash App founder Bob Lee, a verdict reached by a San Francisco jury after seven days of deliberations.
Some 13 oz. bags of Lay's Classic Potato Chips may contain an undeclared allergen, according to the snack company.
California Gov. Gavin Newsom issued an emergency proclamation on Wednesday in response to growing concerns over bird flu cases in the state and across the country.
Researchers at Stanford University believe a newly developed AI tool could help in the fight against cancer and other diseases.
Striking San Francisco hotel workers are attempting to discourage people from attending a major healthcare conference in January.
At least 364 pertussis cases were reported, marking the worst Thanksgiving week on record.
Over half of Americans see the drones that have been spotted over the East Coast as a threat to the U.S.
Fremont's recently elected Mayor Raj Salwan is blazing a new trail as the first Indian-American to lead the East Bay city.
The Senate confirmed two more judges to the federal bench on Friday, giving President Biden a total of 235 since he took office.
San Mateo County emergency officials are developing a new method of communication to reduce misinformation and confusion during earthquake and tsunami threats, following a massive earthquake that struck near Humboldt County in early December.
California regulators approved two more rate hike requests by Pacific Gas and Electric Thursday night, making it six this year.
Police in Santa Cruz have arrested a man on suspicion of a hate crime after a LGBTQ+ bar in the city's downtown was vandalized early Tuesday morning.
The building located off Folsom Street will include 42 units for young adults ages 18 to 24.
San Jose State's volleyball team was the subject of a national debate about women in sports.
A look at key dates before and during the San Jose State women's volleyball season marked by multiple forfeits by teams claiming the Spartans have a transgender player.
San Jose State says it's disappointed that Boise State forfeited its semifinal match in the Mountain West women's volleyball tournament but is focused on the future.
Veteran East Bay R&B band Tower of Power plays classic funk and soul hits along with some seasonal holiday standards to the Fox Theater in Oakland Saturday night.
Surviving members of the Grateful Dead, Bobby Weir, Bill Kreutzmann, and Mickey Hart, revisit the Great American Music Hall in San Francisco.
One spectacular holiday light display in the East Bay takes its central inspiration not from Santa or Christmas elves, but canines.
Tory Lanaz, who is serving a 10-year prison sentence for shooting Megan Thee Stallion in the feet, is harassing her from prison through surrogates, the petition alleges.
Comedian Nikki Glaser, known for her honest style, is gearing up to host the 82nd Annual Golden Globes.
Ever since the COVID-19 pandemic, the Oakland Unified School District has seen an alarming spike in the number of unhoused students in the school system who deal with a host of challenges far beyond what most children face.
Meteorologist and CBS News Bay Area's resident pilot Lt. Jessica Burch got a treat during Fleet Week, taking to the skies with one of the Blue Angels.
A Bay Area man discovered his devastating loss left him with a new opportunity to rethink how he lives -- follow his journey in virtual reality, 360-degree video.
A groundbreaking medical study involving the UCSF Medical Center has shown some colorectal cancer patients can safely skip radiation treatment and enjoy a potentially higher quality of life.
Every day, San Francisco bar pilot Captain Zach Kellerman goes through what might just be the world's most dangerous commute.
Here's a look at the weather forecast Sunday evening.
As many families are starting to reunite for the holidays, we asked several Bay Area residents to share something good that happened to them.
Bay Area airports are expecting a busy holiday traveling period, with the busiest days likely to be the days after Christmas.
CBS News Bay Area morning edition headlines for Dec. 22, 2024. Watch full newscasts streamed at the CBS SF website or on the app.
with Zoe Mintz.
It's the most wonderful time of the year for a South Bay woman who has played Mrs. Claus for more than 40 years for the children of North San Jose's Alviso District.
For residents of the Oakland Hills, the prospect of another wildfire always remains a concern. This week's Jefferson Awards winner has made it his mission to make the hills and other high-risk areas safer.
In East Palo Alto -- where state education numbers show more than nine in ten public school students are low income and more than half are English learners -- many are finding hope and connection at the Boys & Girls Clubs of the Peninsula.
This week's Jefferson Award winner is Army veteran who continues to live a life of service into his 80s, by feeding hundreds of San Francisco families a week.
An Oakland woman has brought the joy of dance and an appreciation for African American culture to performers and audiences for 52 years.
A Bay Area man who overcame tremendous obstacles to excel in school has made it his mission to gear up other students for success in the classroom and in life.
For Students Rising Above scholar Josh Collins it took moving across the country to realize the value of his Bay Area family.
Samir Hooker had to grow up fast after his stepfather was shot dead 12 years ago. Now he is watching over his mom and sister while attending UC Berkeley.
It's hard enough to graduate from one of the most prestigious schools in the country when you're the first in your family to go to college. Imagine doing that while you're also trying to protect your parents from being deported?
Some students who are the first in their families to go to college face the challenge of balancing a rigorous academic load while still working to help support their family back home.