Patricia Arquette

Actress Patricia Arquette is seen here playing the love interest in the 2000 Adam Sandler comedy, "Little Nicky." The role sadly got her nominated for a Razzie Award for Worst Supporting Actress, though now her awards are more positive in nature.

From left, actors John Travolta, Kelly Preston, Patricia Arquette and Thomas Jane attend the Los Angeles premiere of the "The Punisher" on April 12, 2004 in Hollywood, Calif. Though Jane proposed to Arquette in 2002, the couple got around to marrying last summer.

Arquette attends the 68th Annual Academy Awards with her then-husband Nicolas Cage, who was nominated for Best Actor for his role in 1995's "Leaving Las Vegas." Cage won the award that evening, but the couple eventually split in 2001.

Arquette poses with her Emmy for Outstanding Lead Actress in a Drama Series for her role on NBC's "Medium" at the 57th Annual Emmy Awards held on Sept. 18, 2005. She is nominated once again this year for the same role.

Actress Sofia Vassilieva, left, poses with Arquette as they attend the NBC TCA party on Jan. 22, 2006, in Los Angeles. Arquette plays Vassilieva's mother in the NBC drama "Medium," a show about a psychic who uses her abilities to solve mysteries for the police.

From left, actors Thomas Jane, Patricia Arquette, Rosanna Arquette, Alexis Arquette, Richmond Arquette, David Arquette and Courteney Cox Arquette attend the AFI Associates luncheon honoring Hollywood's Arquette family with the 6th Annual "Platinum Circle Award" on May 10, 2006.

Patricia Arquette poses with Prince Albert II of Monaco at the Palais during the 46th annual Monte Carlo Television Festival on June 29, 2006. Though she mainly focuses now on her TV show, Arquette still occasionally stars in movies, most recently last year's "Fast Food Nation."

Actress Patricia Arquette and her husband, actor Thomas Jane, arrive at the 13th Annual Screen Actors Guild Awards on Jan. 28, 2007, in Los Angeles. Arquette was nominated for Outstanding Performance by a Female Actor in a Drama Series for the second year in a row, but has yet to win the award.