Oprah Winfrey waves as her show taped for the last time on Tuesday, May 24, 2011, in Chicago. The episode aired on May 25, ending her "The Oprah Winfrey Show" after 25 years on the air.
Oprah Winfrey attends "Surprise Oprah! A Farewell Spectacular" at the United Center on May 17, 2011, in Chicago.
Talk-show host Oprah Winfrey, right, interviews author James Frey in New York on April 30, 2011, during taping for "The Oprah Winfrey Show." The interview will stretch over two episodes to be aired on May 16-17.
Oprah Winfrey and Maria Shriver speak during the 2010 Women's Conference on Oct. 26, 2010, in Long Beach, Calif.
President Obama and First Lady Michelle Obama appear with Oprah Winfrey during a taping of Winfrey's talk show in Chicago, April 27, 2011.
Oprah Winfrey listens to a reporter's question during the Discovery Communications Television Critics Association winter media tour in Pasadena, Calif., on Jan. 6, 2011.
Oprah Winfrey at the OWN: Oprah Winfrey Network's 2011 TCA Winter Press Tour Cocktail Party on Jan. 6, 2011, in Pasadena, Calif.
On Nov. 20, 2009, Oprah Winfrey announces during a live broadcast of "The Oprah Winfrey Show" in Chicago that her daytime television show, the foundation of a multibillion-dollar media empire with legions of fans, will end its run in 2011 after 25 seasons on the air.
Oprah Winfrey, left, and Tyler Perry, arrive for the premiere of the film "Precious: Based on the Novel 'Push' by Sapphire," at AFI Fest 2009 in Los Angeles, Sunday, Nov. 1, 2009. The two were executive producers of the movie.
Oprah Winfrey, smiles at Duke president Richard Brodhead, after receiving her honorary degree from Duke University during graduation exercises at Duke University on Sunday, May 10, 2009, in Durham, N.C.
Then-Democratic presidential hopeful Sen. Barack Obama, D-Ill., is seen with his wife Michelle, left, and Oprah Winfrey, right, as they take part in a campaign rally at Williams Brice Stadium in Columbia, S.C., Sunday, Dec. 9, 2008.
Actress Jennifer Aniston, left, poses with Oprah Winfrey during taping of "The Oprah Winfrey Show" on Wednesday, Nov. 12, 2008, in Chicago.
Talk show host Oprah Winfrey holding a copy of her book club choice, Sidney Poitier's autobiography "The Measure of a Man," during taping of "The Oprah Winfrey Show" Thursday, Jan. 25, 2007 in Chicago.
Former President Clinton reads an excerpt from his book "My Life" to Winfrey during taping of "The Oprah Winfrey Show," June 21, 2004. Because of her on-air book club, Winfrey was presented with the National Book Foundation's 50th anniversary gold medal.
Winfrey arrives at the Kodak Theatre for the 76th annual Academy Awards ceremony in Los Angeles, Feb. 29, 2004. Winfrey, who was a presenter, is wearing a gown designed by Gianfranco Ferre. In 1985, she received Oscar and Golden Globe nominations for her work in "The Color Purple."
Winfrey celebrates the award she won for favorite talk show host at the 30th Annual People's Choice Awards, Jan. 11, 2004, in Pasadena, Calif.
Winfrey accepts a special Bob Hope Humanitarian Award during the 54th Annual Primetime Emmy Awards, Sept. 22, 2002. Her talks show has received numerous daytime Emmy awards and she has won the International Radio and Television Society's "Broadcaster of the Year" award.
Actor and Irish rock star Bono, left, sports lipstick from Winfrey during taping of "The Oprah Winfrey Show," Sept. 17, 2002, in Chicago. The two talked about their mutual concerns about issues confronting Africa.
President George W. Bush greets Winfrey with a kiss, Sept. 19, 2000, during his first run for the White House. In the talk-show business since 1984, when she first hosted a local Chicago show, Winfrey has interviewed hundreds of celebrities and statesmen, including several presidents.
Winfrey stands in front of the cover of the premiere issue of O, The Oprah Magazine, at a press breakfast in New York, April 17, 2000.
Rosie O'Donnell and Winfrey display their Emmy statuettes during the 1998 Daytime Emmy Awards at Radio City Music Hall in New York, May 15, 1998. O'Donnell and Winfrey tied in the category of "Outstanding Talk Show Host."
Winfrey smiles as she talks to the media after a jury ruled in her favor in Amarillo, Texas, Feb. 26, 1998. Jurors rejected a lawsuit by Texas cattlemen who claimed Winfrey's televised comments about mad cow disease caused the beef market to plummet, costing them millions of dollars.
Ellen DeGeneres, left, playing character Ellen Morgan, discusses her fears about coming out as a lesbian with her therapist, played by Oprah Winfrey, during a taping of the sitcom "Ellen," in Burbank, Calif., on March 14, 1997.
Winfrey arrives at the 1995 Essence Awards in New York with her longtime boyfriend, businessman Stedman Graham, May 12, 1995. Together since the mid-1980s, the couple has said they have no plans to marry.
Oprah Winfrey is seen interviewing Michael Jackson during her television show in 1993.
Oprah Winfrey shows off her new figure as she stands in front of 68 pounds of fat inside a toy wagon, in Chicago on Nov. 16, 1988.
Winfrey appears at the wedding of Maria Shriver and Arnold Schwarzenegger, in Hyannis, Mass., April 26, 1986. Winfrey and Shriver became friends in the late '70s when they both worked at WJZ-TV in Baltimore, where Winfrey co-anchored the 6 p.m. newscast.
Winfrey puts her feet up as she relaxes in her office following a morning broadcast in Chicago, Ill., Dec. 18, 1985. At the age of 31, Winfrey's self-titled talk show was about to enter national syndication, and her movie debut, "The Color Purple," was on its way to theaters.