Drew Barrymore

Actress Drew Barrymore stops for a photo backstage after winning the Golden Globe for Best Actress in a Mini-Series or TV Movie for "Grey Gardens" at the 67th Annual Golden Globe Awards on Sunday, Jan. 17, 2010, in Beverly Hills, Calif.

Drew Barrymore arrives at the Los Angeles premiere of the film "Whip It" on Tuesday, Sept. 29, 2009. "Whip It" marks Barrymore's directorial debut, and she also has a role in the film. Born into an acting dynasty, Barrymore got her start as a child star, went to rehab by age 13 and established herself as a successful adult actress.

6. E.T. The Extra-Terrestrial (1982) — Universal Pictures

Born in California in 1975, Drew Barrymore is a part of the famous Barrymore family of actors, dating back to her great-great-grandparents. She made her acting debut in a commercial at 11 months old, and made her film debut in 1980's "Altered States." Her most memorable childhood role, however, was that of Gertie in 1982's "E.T. the Extra-Terrestrial," which was directed by her godfather, Stephen Spielberg.

In the wake of her childhood stardom, Drew Barrymore entered a notorious battle with drugs and alcohol. She had her first drink at age 9, was smoking marijuana by 10 and snorting cocaine at 12. She entered rehab when she was 13, and went back a second time at age 14 after a suicide attempt. She described this period in her life in her 1990 biography, "Little Girl Lost." She is seen here in a 1992 photo.

After emerging from rehab, Barrymore, seen here in 1996, took on roles in films like "Poison Ivy," "Boys on the Side" and "Guncrazy." In 1994, she married bar owner Jeremy Thomas, 31, but filed for divorce less than two months later. She also posed nude for Playboy in 1995 and notoriously danced on David Letterman's desk and flashed her breasts to the host during a 1995 guest appearance on the "Late Show."

Drew Barrymore's return to prominence continued with a cameo in 1995's "Batman Forever" and a small role in the 1996 horror film "Scream" (seen here). She also made a name for herself in romantic comedies, starring in ones such as "The Wedding Singer," with Adam Sandler, and "Home Fries" alongside Luke Wilson, whom she briefly dated.

In 1995, Drew Barrymore, seen here accepting the Hasty Pudding award at Harvard University in Cambridge, Mass., in 2001, founded her own production company called Flower Films, which has gone on to produce a number of her films, including "Never Been Kissed," "Charlie's Angels," "50 First Dates" and "He's Just Not That Into You."

Drew Barrymore and comedian Tom Green, seen here in 2001, began dating after Green filmed a cameo in Barrymore's film "Charlie's Angels: Full Throttle." Barrymore stood by Green during his battle with testicular cancer, and the two wed on July 7, 2001. Green filed for divorce after five months of marriage.

Actresses Cameron Diaz, right, Drew Barrymore, center, and Lucy Liu arrive at the premiere of "Charlie's Angels: Full Throttle," Wednesday, June 18, 2003, in Los Angeles.

Drew Barrymore poses for a photo with her newly unveiled star on the Hollywood's Walk of Fame, Tuesday, Feb, 3, 2004, in the Hollywood area of Los Angeles.

Actors Drew Barrymore, left, and Adam Sandler accept the award for "Choice Date Movie" for their work in "50 First Dates" at the Teen Choice Awards in Universal City, Calif., Sunday, Aug. 8, 2004. The two also starred together in the romantic comedy "The Wedding Singer."

Drew Barrymore arrives for the 77th Academy Awards Sunday, Feb. 27, 2005, in Los Angeles. At the time, Barrymore was dating Strokes drummer Fabrizio Moretti, whom she met at a concert in 2002. Their five-year relationship ended in 2007.

Drew Barrymore and Jimmy Fallon are seen in a scene from the 2005 film "Fever Pitch." The film, a romantic comedy taking place during the Boston Red Sox's 2004 World Series playoffs, filmed at the games and even while the team rushed the field after they won the series. "Being at the winning game was a life experience," Barrymore told People magazine at the time.

Drew Barrymore arrives at the Los Angeles premiere of "We Are Marshall" in the Hollywood section of Los Angeles on Thursday, Dec. 14, 2006.

Drew Barrymore, a cast member in the film "Music and Lyrics," poses at the premiere of the film in Los Angeles, Wednesday, Feb. 7, 2007. Hugh Grant also starred in the film, which was produced by Barrymore's production company, Flower Films.

Drew Barrymore appears on MTV's "Total Request Live," Wednesday, Feb. 14, 2007, at MTV's Times Square studios in New York. Barrymore is the youngest person to ever host "Saturday Night Live" -- she took on hosting duties when she was 7 years old.

Justin Long and Drew Barrymore arrive at "A Night to Benefit Raising Malawi and UNICEF" at United Nations headquarters on Feb. 6, 2008. After her breakup with Fabrizio Moretti, Barrymore and Long starred together in the romantic comedy "He's Just Not That Into You" and began dating. The couple broke up in July 2008, but are reuniting on the big screen again for the upcoming film "Going the Distance."

Actress Drew Barrymore vamps on the red carpet at the premiere of her TV movie "Grey Gardens" in New York, Tuesday, April 14, 2009, in New York. Her role in the movie, playing Little Edie, earned her an Emmy nomination.

Actress Drew Barrymore speaks to gay marriage supporters during a rally and march in response to the California Supreme Court's ruling on Proposition 8 in West Hollywood, Calif., on Tuesday, May 26, 2009.

Drew Barrymore arrives at the 61st Primetime Emmy Awards on Sunday, Sept. 20, 2009, in Los Angeles.