Christina Applegate

Christina Applegate with "Married with Children" castmates David Faustino, Katey Sagal and Ed O'Neill in 1988. Applegate played in many TV series before landing her breakout role on the show in 1987. "Married" ran for 10 years.

Applegate, center, in a scene with co-stars Cameron Diaz and Selma Blair from 2002's "The Sweetest Thing."

Applegate with Jennifer Aniston in a scene from "Friends." Applegate guest-starred in episodes of the show as Rachel's self-absorbed sister Amy.

Actress Christina Applegate kisses her award for "Outstanding Guest Actress in a Comedy Series" for her work on "Friends" at the 2003 Emmys.

Christina Applegate poses for photographers before the premiere of the film "Anchorman: The Legend of Ron Burgundy" in 2004. The actress is the daughter of record producer Robert Applegate and singer-actress Nancy Priddy.

Christina Applegate and Will Ferrell as Veronica Corningstone and Ron Burgandy in 2004's "Anchorman: The Legend Of Ron Burgandy."

Christina Applegate reacts during the curtain call for the opening night performance of the musical "Sweet Charity" in New York in 2005.

Actress Christina Applegate poses with ex-husband Johnathon Schaech at the Tony Awards in 2005. Applegate won the Tony for Best Lead Actress In A Musical for her performance in the revival of "Sweet Charity."

Christina Applegate on the red carpet at the 2008 Producers Guild Awards in Beverly Hills, Calif.

Applegate starred in the ABC series "Samantha Who?," playing a woman who suffers from amnesia and is forced to find her true identity. ABC cancelled "Samantha" on May 18, 2009, but Applegate's work on the show earned her a second Emmy nomination for Outstanding Lead Actress in a Comedy Series for her role as Samantha Newly.

Christina Applegate made her red-carpet return after having breast cancer surgery in 2008 with a dramatic, sweeping one-shoulder gown in ice blue with metallic details.

David Boreanaz kisses Christina Applegate as he presents her with the favorite female TV star award at the 35th Annual People's Choice Awards on Wednesday Jan. 7, 2009, in Los Angeles.

Christina Applegate poses backstage with the Favorite Female TV Star award at the 35th Annual People's Choice Awards on Wednesday Jan. 7, 2009, in Los Angeles.

Christina Applegate, nominated for best actress in a television series, comedy or musical for "Samantha Who?," poses as she arrives at the 66th Annual Golden Globe Awards on Sunday, Jan. 11, 2009, in Beverly Hills, Calif.

Christina Applegate, center, performs the song "Frozen River" at the Independent Spirit Awards in Santa Monica, Calif. on Saturday, Feb. 21, 2009.

Christina Applegate walks on stage at the 16th Annual EIF Revlon Run/Walk For Women in Los Angeles on Saturday, May 9, 2009.

Christina Applegate is seen backstage at the TV Land Awards on Sunday April 19, 2009 in Universal City, Calif.