Billy Crystal in film

Billy Crystal and Meg Ryan in the iconic 1989 film "When Harry Met Sally." The movie asks the age-old question, "Can a man and a woman be friends, without sex getting in the way?"

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Billy Crystal plays a movie publicist who is trying to cope with his movie's co-stars break-up in the 2001 film "America's Sweethearts."

Robert De Niro and Billy Crystal in the 1999 film, "Analyze This." Crystal plays a therapist trying to help a mob boss deal with his feelings.

Billy Crystal and Robert DeNiro joined forces again in "Analyze That," the 2002 sequel to the "Analyze This."

Billy Crystal and Jack Palance in the 1991 film, "City Slickers." Crystal plays a man with a mid-life crisis who goes on a cattle drive vacation with his friends.

Billy Crystal, Jon Lovitz, Jack Palance and Daniel Stern in the 2004 sequel "City Slickers II: The Legend of Curly's Gold." The sequel follows the Crystal and his co-stars as they try to discover the secrets of a treasure map that belonged to their late guide Curly.

Woody Allen, Elisabeth Shue and Billy Crystal in the 1997 film "Deconstructing Harry," about a writer suffering from writer's block who has some interesting guests that come to haunt him.

Robin Williams and Billy Crystal star in the 1997 film "Fathers' Day," in which a woman cons two old boyfriends into searching for her runaway son by convincing both that they are the boy's father.

Billy Crystal and Debra Winger in the 1995 film "Forget Paris." The film is about a basketball referee and an airline employee, their meeting and the difficulties they encounter in their relationship.

Billy Crystal and Danny DeVito in the 1987 film "Throw Momma from the Train." An ex-husband and a put-upon momma's boy look to each other in an effort to kill the offensive women in their lives.

Billy Crystal voiced the character Mike Wazowski, character seen at left, in the Disney/Pixar hit, "Monsters Inc."

Crystal is slated to reprise his voice role as Mike Wazowski in "Monsters University," a sequel to "Monsters Inc."

Billy Crystal and Gheorghe Muresan in the 1997 film "My Giant." Crystal plays a Hollywood agent who stumbles upon Max, a giant living in Romania, and tries to get him into the movies.

Billy Crystal and Carol Kane in the 1987 film "The Princess Bride." An iconic role for Crystal, Miracle Max is known for the line, "Have fun storming the castle," and for bringing the movie's protagonist back from "mostly dead" status.

Billy Crystal, center, with his co-stars in "Parental Guidance," his latest film. Crystal plays a grandfather who looks after his grandchildren when their parents leave town for work.

Billy Crystal in the 1986 film "Running Scared." Crystal plays a street-wise cop in Chicago.

Billy Crystal in the 1992 film "Mr. Saturday Night."