Jared Goff threw two of his four touchdown passes to Amon-Ra St. Brown, David Montgomery and Jahmyr Gibbs combined for three rushing touchdowns, and the Detroit Lions routed the Jacksonville Jaguars 52-6 on Sunday.
The NFC-leading Lions (9-1) have won eight straight and nine of their first 10 games in a season for the first time since 1934.
Detroit's winning margin of 46 points was the largest in franchise history, and it handed Jacksonville its biggest-ever defeat. The Lions also set a franchise record in total yards with 644.
The Jaguars (2-9) have lost four consecutive games for the second time this season and 14 of 17 since last year, a series of slumps that may cost coach Doug Pederson his job.
Jacksonville rookie Cam Little made a career-best 59-yard field goal on the game-opening drive and closed the first half with another field goal.
In between those kicks, the Lions scored four touchdowns to take a 28-3 lead, and they didn't take it easy on the Jags after halftime.
Montgomery started the scoring barrage with a 2-yard run and Gibbs followed with a 1-yard run in the second quarter. Montgomery had a 6-yard run for his second score and Goff threw a 27-yard pass to St. Brown in the second quarter, extending the receiver's franchise record with a touchdown catch to eight straight games.
The Lions didn't take their foot off the gas in the Motor City, going ahead 49-6 early in the fourth quarter after Goff threw a 64-yard touchdown pass to Jameson Williams, a 5-yarder to Brock Wright and a 9-yard strike to St. Brown on the right side of the end zone.
Goff finished 24 of 29 for 412 yards and four touchdowns. He had a perfect passer rating, a week after his career-high five interceptions didn't stop Detroit from rallying from a 16-point deficit to beat AFC South-leading Houston.
St. Brown (161) and Williams (124) had single-game highs for yards receiving. Montgomery and Gibbs combined for 218 yards of offense.
Hendon Hooker gave Goff a break midway through the fourth and set up Jake Bates' 54-yard field goal. Detroit ran out the clock in the final minutes, mercifully choosing not to score again.
Detroit's defense got a boost from newly acquired end Za'Darius Smith, who had a sack in his debut with the franchise.
Jacksonville's Mac Jones struggled, starting for a second straight week in place of the injured Trevor Lawrence. He was 17 of 29 for 138 yards yards and was picked off near Detroit's end zone late in the third quarter, floating a pass that Kerby Joseph took advantage of for his seventh interception this season.
Injuries
Jag: Lawrence (shoulder) missed his second straight game and RB Tank Bigsby (ankle) was also inactive. CB Tyson Campbell (shoulder), C Mitch Morse (eye) and WR Gabe Davis (knee) were hurt during the game.
Lions: LB Alex Anzalone left the game with a forearm injury, CB Carlton Davis played sparingly after having a hand injury earlier in the week and TE Sam LaPorta (shoulder) was inactive.
Up next
The Lions play at Indianapolis on Sunday.
Bates kicks 54-yard field goal
Lions kicker Jake Bates adds 3 more points for Detroit following a 54-yard field goal.
Detroit now leads the Jacksonville Jaguars 52-6 with under eight minutes left in the game.
St. Brown scores again for Lions
The Lions lead the Jacksonville Jaguars 49-6 in the fourth quarter after a 9-yard touchdown reception from Amon-Ra St. Brown.
Goff throws his 3rd touchdown of the day
Lions quarterback Jared Goff now has three touchdowns on the day following a 5-yard pass to Brock Wright with under five minutes left in the third quarter.
Detroit leads the Jaguars 42-6.
Jameson Williams kicks off second half with touchdown
A 64-yard touchdown reception by Jameson Williams early in the third quarter now has the Lions leading the Jacksonville Jaguars 35-6.
Jaguars kick field goal to end the first half
Jaguars kicker Cam Little kicked a 35-yard field goal with time expiring in the first half.
The Lions lead 28-6 going into halftime.
St. Brown catches 27-yard touchdown reception
The Lions lead the Jaguars 28-3 after a 27-yard touchdown reception by Amon-Ra St. Brown.
There are just under three minutes left in the second quarter.
Lions increase lead following Montgomery touchdown run
Lions running back David Montgomery scored his second rushing touchdown of the day in the second quarter, increasing the Lions lead over the Jaguars to 21-3.
Montgomery scored on a 6-yard rush.
Gibbs scores for the Lions
The Detroit Lions lead 14-3 over the Jacksonville Jaguars after a 1-yard touchdown run from running back Jahmyr Gibbs.
There's under 13 minutes left in the second quarter.
Montgomery gives Lions the lead with rushing touchdown
The Lions respond to the Jaguars' field goal with a 2-yard rushing touchdown from running back David Montgomery.
After an extra point kick from Jake Bates, Detroit leads Jacksonville 7-3 with just under five minutes left in the first quarter.
Jaguars kicker hits 59-yard field goal
The Jacksonville Jaguars are on the board first after a 59-yard field goal kick by Cam Little.
The Jaguars lead 3-0 with less than 10 minutes to go in the first quarter.
One-on-one with Za'Darius Smith
Defensive end Za'Darius Smith, who the Lions recently acquired in a trade, is expected to make his debut on Sunday.
CBS News Detroit sports anchor Rachel Hopmayer recently spoke with Smith to get his feelings about his new team, how he's planning to help and more.
Watch the full interview here.